Mycophenolate Mofetil and Sirolimus Combination in Renal Transplantation
نویسندگان
چکیده
منابع مشابه
The evolving role of mycophenolate mofetil in renal transplantation.
Mycophenolate mofetil (MMF) is an ester prodrug tial interest in organ transplantation is the inhibitory with higher bioavailability than the active agent, effect of MPA on the proliferation of human arterial mycophenolic acid (MPA).1 MPA inhibits inosine smooth muscle cells in vitro. Arterial disease plays monophosphate (IMP) dehydrogenase, an enzyme a central role in chronic graft rejection, ...
متن کاملEvaluation of tolerability of enteric-coated mycophenolate sodium versus mycophenolate mofetil in de novo renal transplantation.
INTRODUCTION Mycophenolate mofetil (MMF), pro-drug mycophenolic acid (MPA) is an immunosuppressive effective in the prophylaxis of acute rejection, but associated with gastrointestinal adverse events. Mycophenolate sodium (MPS) with enteric coating was developed with intention of reducing such gastrointestinal adverse events associated with MPA. OBJECTIVE To evaluate the tolerability of EC-MP...
متن کاملSirolimus in renal transplantation.
Acute rejection episodes are now as low as 5-20% in the first year after renal transplantation; however, graft half-life has remained almost unchanged in the last decade. This statistic is mainly attributable to the side effects of immunosuppression, with loss of allografts due to the chronic allograft nephropathy that is a consequence of calcineurin inhibitor toxicity or hypertension. Patient ...
متن کاملMycophenolate mofetil attenuates renal ischemia/reperfusion injury.
Immunosuppressive agents may have an impact on ischemia/reperfusion (I/R) injury. The immunosuppressant mycophenolate mofetil (MMF) presents properties that can attenuate such injury. This study investigated the effects of MMF on renal I/R injury. Male Wistar rats received MMF (20 mg/kg per d) or vehicle by gavage beginning 2 d before ischemia and maintained during the entire study. Ischemic in...
متن کاملAvoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids.
Cyclosporine (CsA) has been implicated in both acute and chronic graft dysfunction. The addition of humanized IL-2 receptor antibody daclizumab (DZB) to CsA-based immunosuppression decreases the rate of acute renal transplant rejection. Therefore, 45 patients were evaluated in an immunosuppressive protocol that included DZB, mycophenolate mofetil (MMF), and steroids without CsA. This was a pros...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2006
ISSN: 1600-6135,1600-6143
DOI: 10.1111/j.1600-6143.2006.01398.x